>>4 It's still true of USB 3.0. SATA also recently upgraded and is beyond 3.0 speeds (although a lot closer than before)
It is important to note that most of the game's 'execution' occurs in memory on your physical computer, so the only reason any given drive will be faster is if it can transfer data to memory faster. Being able to write faster doesn't make much of a difference. If you are saving or loading, then it would have to write to the stick, and I suppose it would write faster, but it still has to transfer that data from memory to be written to the stick, and that takes way longer through USB than SATA.
Basically, this means loading and saving will definitely be longer, but not much else I believe. The flash drive is not faster, but it's not that much slower when playing games overall.