Now I don't know about what you guys think, but personally I think the Legacy of Kain games are amazing, I has been around 6-7 years since LoK:Defiance and I was worried the series was dead. So I had a look around and I found this:

http://www.computerandvideogames.com/411534/legacy-of-kain-nosgoth-is-in-development-square-enix-confirms/

http://n4g.com/news/1275156/new-game-set-in-legacy-of-kain-universe-in-the-works

http://forums.gametrailers.com/Gam-F6/PC-F13/Leg-T1281548/?f=13&t=1281548

So by the sounds of it, its going to be a multiplayer spin-off based in the same world, and while im psyched about that I cant help but wish they would create a single player sequel, seeing as at the end of defiance they left room for a sequel.