>>11 I think it would be pretty trivial to move it to America. I don't think there were any tightly knit references to Japanese culture that could not be avoided in a remake.
Also, re: casting, Section 9 had some of the least Japanese looking people in the entire series. Togusa probably looks the 'most' Japanese since he was not prosthetic. I think the reality is they could have cast an Asian actress, but they wanted a big name to attract more viewers.
I would also recommend watching the original movie, the sequel Innocence, and GITS: Stand Alone Complex.
I just hope they keep the detail-heavy aspects of the original. There was a lot of technology that was only shown on screen once or twice, in some kind of day-to-day situation, that had a lot of creativity put into it.